Mast cell leukemia

Mast cell leukemia is a rare and aggressive subtype of systemic mastocytosis characterized by the proliferation of mast cells in the bone marrow and other organs. It is classified as a myeloproliferative neoplasm and is associated with a poor prognosis.

Signs and symptoms

Patients with mast cell leukemia often present with symptoms related to the infiltration of mast cells into various organs. These can include fatigue, weight loss, fever, and abdominal pain. In addition, the release of histamine and other mediators from mast cells can cause flushing, itching, diarrhea, and anaphylactic reactions.

Diagnosis

The diagnosis of mast cell leukemia is based on the presence of mast cells in the bone marrow and other tissues, as well as the presence of certain mutations in the KIT gene. Other diagnostic tests can include blood tests, bone marrow examination, and genetic testing.

Treatment

Treatment for mast cell leukemia is typically aggressive and can include chemotherapy, stem cell transplantation, and targeted therapies such as tyrosine kinase inhibitors.

Prognosis

The prognosis for mast cell leukemia is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time.

See also

• Mastocytosis
• Leukemia
• Myeloproliferative neoplasm

References

Mast cell leukemia Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski