Mebutizide

Mebutizide

Mebutizide is a diuretic and antihypertensive medication that belongs to the thiazide class of drugs. It is primarily used in the treatment of hypertension (high blood pressure) and edema (fluid retention).

Pharmacology

Mebutizide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron. This action prevents the reabsorption of sodium and chloride ions, leading to an increase in the excretion of water and electrolytes. This diuretic effect helps to lower blood pressure and reduce fluid retention.

Clinical Use

Mebutizide is used in the management of hypertension, either alone or in combination with other antihypertensive agents. It is also used to treat edema associated with conditions such as congestive heart failure, cirrhosis, and nephrotic syndrome.

Side Effects

Like other thiazide diuretics, Mebutizide can cause a range of side effects. These may include hypokalemia (low potassium levels), hyponatremia (low sodium levels), and hyperuricemia (high uric acid levels). Other potential side effects include dizziness, headache, and gastrointestinal disturbances.

Contraindications

Mebutizide is contraindicated in patients with known hypersensitivity to thiazide diuretics or sulfonamide-derived drugs. It should also be used with caution in patients with severe renal or hepatic impairment.

Interactions

Mebutizide may interact with a number of other medications, including digoxin, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can affect the efficacy of the medication and increase the risk of side effects.

See Also

• Thiazide
• Hypertension
• Edema