Medroxyprogesterone caproate

Medroxyprogesterone caproate (MPC) is a synthetic progestin that is used in hormone replacement therapy, contraceptives, and in the treatment of gynecological disorders. It is a derivative of progesterone and is also known as depo-subQ provera 104 or depo-provera.

Pharmacology

MPC acts by binding to the progesterone receptor, inhibiting the release of gonadotropins from the pituitary gland, and preventing follicular maturation and ovulation. As a result, it has potent antigonadotropic effects and weak glucocorticoid activity.

Medical uses

MPC is used in the treatment of endometriosis, uterine bleeding, amenorrhea, and abnormal uterine bleeding. It is also used as a contraceptive in the form of depot injections, which provide effective contraception for three months.

Side effects

Common side effects of MPC include weight gain, mood changes, acne, breast tenderness, and changes in menstrual bleeding patterns. Less common side effects include depression, anxiety, hair loss, and osteoporosis.

Contraindications

MPC is contraindicated in individuals with thrombophlebitis, liver disease, breast cancer, or a history of stroke or blood clots.

See also

• Progesterone
• Progestin
• Hormone replacement therapy
• Contraceptive

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