Metal-binding protein

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Metal-binding proteins are a class of proteins that play a crucial role in binding and transporting metal ions within living organisms. These proteins are essential for various biological processes, including metabolism, cell signaling, and gene regulation.

Structure[edit | edit source]

Metal-binding proteins typically contain specific amino acid residues, such as histidine, cysteine, and aspartic acid, that serve as binding sites for metal ions. These residues form coordination complexes with the metal ions, allowing the protein to selectively bind and transport specific metals.

Function[edit | edit source]

Metal-binding proteins serve diverse functions in biological systems. For example, ferritin is a metal-binding protein that stores and releases iron in a controlled manner, preventing iron toxicity. Metallothionein is another metal-binding protein that plays a role in regulating the levels of essential metals like zinc and copper.

Examples[edit | edit source]

One well-known example of a metal-binding protein is hemoglobin, which binds iron ions and is responsible for transporting oxygen in the blood. Another example is cytochrome c, a protein that contains a heme group with an iron ion and is involved in cellular respiration.

Role in Health and Disease[edit | edit source]

Dysregulation of metal-binding proteins can lead to various health conditions. For instance, mutations in metal-binding proteins like ceruloplasmin can result in disorders such as Wilson's disease, which is characterized by abnormal copper accumulation in the body.

Research and Applications[edit | edit source]

Metal-binding proteins have garnered significant interest in research due to their potential applications in various fields, including biotechnology and medicine. Understanding the mechanisms of metal binding in proteins can lead to the development of novel therapies for metal-related disorders.

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Contributors: Prab R. Tumpati, MD