Metaphedrine
Metaphedrine is a psychostimulant and sympathomimetic drug that is chemically similar to amphetamine. It is also known as methamphetamine hydrochloride and is commonly used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Chemistry[edit | edit source]
Metaphedrine is a member of the phenethylamine and amphetamine chemical classes. It is a chiral compound, and both of its enantiomers display similar potency as substrates at dopamine transporters. Metaphedrine is a potent full agonist of trace amine-associated receptor 1 (TAAR1), which is known to regulate dopamine, norepinephrine, and serotonin in the brain.
Pharmacology[edit | edit source]
Metaphedrine acts primarily by inducing the release of dopamine, norepinephrine, and serotonin from storage vesicles in the presynaptic neuron. This results in an increased concentration of these neurotransmitters in the synaptic cleft, leading to increased postsynaptic receptor activation.
Medical Uses[edit | edit source]
Metaphedrine is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It may also be used off-label for its cognitive enhancement effects, or to help maintain alertness and productivity in long hours of work or study.
Side Effects[edit | edit source]
Common side effects of Metaphedrine include insomnia, appetite loss, and weight loss. More serious side effects may include cardiovascular disease, neurotoxicity, and substance use disorder.
See Also[edit | edit source]
References[edit | edit source]
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