Methscopolamine

What is Methscopolamine?

• Methscopolamine or Methylscopolamine (Pamine; Pamine Forte) is an anticholinergic agent used as adjunctive therapy for the treatment of peptic ulcer.

Methscopolamine

What are the uses of this medicine?

• Methscopolamine or Methylscopolamine (Pamine; Pamine Forte) used as adjunctive therapy for the treatment of peptic ulcer.

Limitations of Use:

• METHSCOPOLAMINE BROMIDE HAS NOT BEEN SHOWN TO BE EFFECTIVE IN CONTRIBUTING TO THE HEALING OF PEPTIC ULCER, DECREASING THE RATE OF RECURRENCE OR PREVENTING COMPLICATIONS.

How does this medicine work?

• Methscopolamine bromide is an anticholinergic agent which possesses most of the pharmacologic actions of that drug class.
• These include reduction in volume and total acid content of gastric secretion, inhibition of gastrointestinal motility, inhibition of salivary excretion, dilation of the pupil and inhibition of accommodation with resulting blurring of vision.
• Large doses may result in tachycardia.

Who Should Not Use this medicine ?

This medicine cannot be used in patients with:

• Glaucoma; obstructive uropathy (e.g., bladder neck obstruction due to prostatic hypertrophy); obstructive disease of the gastrointestinal tract (e.g., pyloroduodenal stenosis); paralytic ileus; intestinal atony of the elderly or debilitated patient; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic megacolon complicating ulcerative colitis; myasthenia gravis.
• who are hypersensitive to methscopolamine bromide or related drugs.

What drug interactions can this medicine cause?

• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Be sure to mention any of the following:

• antipsychotics, tricyclic antidepressants, and other drugs with anticholinergic effects.

• Concomitant administration with antacids may interfere with the absorption of methscopolamine bromide.

Is this medicine FDA approved?

• It was patented in 1902 and approved for medical use in 1947.
• Methscopolamine is an FDA-approved analog to hyoscine butylbromide.

How should this medicine be used?

Recommended dosage:

• The average dosage of Pamine® Tablets is 2.5 mg one-half hour before meals and 2.5 to 5 mg at bedtime.
• A starting dose of 12.5 mg daily will be clinically effective in most patients without the production of appreciable side effects.
• If the patient is experiencing symptoms such as severe abdominal pain or cramping which demand prompt relief, the drug may be started on a daily dosage of 20 mg, administered in doses of 5 mg one-half hour before meals and at bedtime.

Administration:

• Methscopolamine comes as a Pamine Tablets for oral administration and Pamine Forte Tablets for oral administration.
• It is usually taken one-half hour before meals and at bedtime.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Pamine 2.5 mg Tablets for oral administration contain 2.5 mg of methscopolamine bromide.
• Pamine Forte 5 mg Tablets for oral administration contain 5 mg of methscopolamine bromide.

This medicine is available in fallowing brand namesː

• Pamine; Pamine Forte

What side effects can this medication cause?

The most common side effects of this medicine include:

Cardiovascular: Tachycardia, palpitation. Allergic: Severe allergic reaction or drug idiosyncrasies including anaphylaxis. CNS: Headaches, nervousness, mental confusion, drowsiness, dizziness. Special Senses: Blurred vision, dilation of the pupil, cycloplegia, increased ocular tension, loss of taste. Renal: Urinary hesitancy and retention. Gastrointestinal: Nausea, vomiting, constipation, bloated feeling. Dermatologic: Decreased sweating, urticaria and other dermal manifestations. Miscellaneous: Xerostomia, weakness, insomnia, impotence, suppression of lactation.

What special precautions should I follow?

• In the presence of high environmental temperature, heat prostration (fever and heat stroke due to decreased sweating) can occur with drug use.
• Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance treatment with this drug would be inappropriate and possibly harmful.
• Methscopolamine bromide may produce drowsiness or blurred vision. The patient should be cautioned regarding activities requiring mental alertness such as operating a motor vehicle or other machinery or performing hazardous work while taking this drug.
• Use Pamine 2.5 mg/Pamine Forte Tablets with caution in the elderly patients.
• The drug also should be used with caution in patients having hyperthyroidism, coronary heart disease, congestive heart failure, tachyrhythmia, tachycardia, hypertension, or prostatic hypertrophy.
• Progress of the peptic ulcer under treatment should be followed by upper gastrointestinal contrast radiology or endoscopy to insure healing. Stool tests for occult blood and blood hemoglobin or hematocrit values should be followed to rule out bleeding from the ulcer.
• It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when methscopolamine bromide is administered to a nursing woman. Anticholinergic drugs may suppress lactation.

What to do in case of emergency/overdose?

Symptoms of overdose may include:

• neuromuscular blockade leading to muscular weakness and possible paralysis.

Management of overdosage:

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• Pregnancy Category C.
• It also is not known whether methscopolamine bromide can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
• Methscopolamine bromide should be given to a pregnant woman only if clearly needed.

Can this medicine be used in children?

• Safety and efficacy in children have not been established.

What are the active and inactive ingredients in this medicine?

Active Ingredient:

• METHSCOPOLAMINE BROMIDE

Inactive Ingredients:

• CELLULOSE, MICROCRYSTALLINE
• STARCH, CORN
• MAGNESIUM STEARATE

Who manufactures and distributes this medicine?

Manufactured for:

• PharmaDerm
• A division of Fougera Pharmaceuticals Inc.
• Melville, NY USA

Mfd. by:

• Mikart, Inc., Atlanta, GA USA

What should I know about storage and disposal of this medication?

• Store at controlled room temperature 15°-30°C (59°-86°F).
• KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

anticholinergic agents

• Aclidinium
• Atropine
• Homatropine
• Darifenacin
• Dicyclomine
• Fesoterodine
• Flavoxate
• Glycopyrrolate
• Hyoscyamine
• Ipratropium
• Mepenzolate
• Methscopolamine
• Oxybutynin
• Propantheline
• Scopolamine
• Solifenacin
• Tiotropium
• Tolterodine
• Trospium

• Dailymed label info on Methscopolamine
• FDA Methscopolamine

Methscopolamine Resources
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