Methyclothiazide

Methyclothiazide is a diuretic and antihypertensive medication that belongs to the thiazide class of drugs. It is primarily used in the treatment of hypertension (high blood pressure) and edema (fluid retention).

Pharmacology

Methyclothiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron. This action prevents the reabsorption of sodium and chloride ions, leading to an increase in the excretion of water and electrolytes in the urine. This diuretic effect helps to lower blood pressure and reduce fluid retention.

Clinical Use

Methyclothiazide is used in the management of hypertension either as monotherapy or in combination with other antihypertensive agents. It is also used to treat edema associated with various conditions such as congestive heart failure, cirrhosis, and renal disease.

Side Effects

Common side effects of methyclothiazide include dizziness, headache, and nausea. Serious side effects may include electrolyte imbalance, gout, and hypotension.

Contraindications

Methyclothiazide is contraindicated in patients with known hypersensitivity to thiazide diuretics or sulfonamide-derived drugs. It is also contraindicated in patients with anuria or severe renal impairment.

Drug Interactions

Methyclothiazide may interact with other medications such as digoxin, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs), which can affect its efficacy or increase the risk of side effects.

See Also

• Thiazide
• Hypertension
• Edema