Methylenedioxyhydroxyethylamphetamine

From WikiMD.com Medical Encyclopedia

Chemical compound


Methylenedioxyhydroxyethylamphetamine
[[File:
Chemical structure of Methylenedioxyhydroxyethylamphetamine
|frameless|220px|alt=|]]
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Methylenedioxyhydroxyethylamphetamine (MDHOET) is a chemical compound belonging to the substituted amphetamines class. It is structurally related to methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA), which are well-known psychoactive substances. MDHOET is characterized by the presence of a methylenedioxy group attached to the phenyl ring and a hydroxyethyl group attached to the nitrogen atom of the amphetamine backbone.

Chemical Structure and Properties[edit | edit source]

MDHOET is a derivative of amphetamine, featuring a methylenedioxy group (–O–CH2–O–) attached to the 3,4-positions of the phenyl ring. The addition of a hydroxyethyl group (–CH2CH2OH) to the nitrogen atom distinguishes it from other related compounds. This modification can influence the compound's pharmacological properties, including its lipophilicity, solubility, and metabolism.

Pharmacology[edit | edit source]

The pharmacological effects of MDHOET are not well-documented, but it is presumed to act similarly to other substituted amphetamines. These compounds typically function as central nervous system stimulants, affecting the release and reuptake of neurotransmitters such as dopamine, serotonin, and norepinephrine. The presence of the hydroxyethyl group may alter its interaction with monoamine transporters and receptors, potentially affecting its potency and duration of action.

Synthesis[edit | edit source]

The synthesis of MDHOET involves the introduction of a hydroxyethyl group to the nitrogen atom of the amphetamine structure. This can be achieved through various chemical reactions, including reductive amination or alkylation of the corresponding amine. The methylenedioxy group is typically introduced through the use of safrole or its derivatives as starting materials.

Legal Status[edit | edit source]

MDHOET, like many other substituted amphetamines, may be subject to legal restrictions in various jurisdictions. Its legal status can vary depending on national and international drug control laws. In some countries, it may be classified as a controlled substance due to its structural similarity to known psychoactive drugs.

Potential Uses and Research[edit | edit source]

Research on MDHOET is limited, and its potential uses are not well-explored. However, compounds in this class are often studied for their effects on the central nervous system and potential therapeutic applications. Further research could elucidate its pharmacological profile and potential benefits or risks.

Related Pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD