Monoblastic leukemia

Monoblastic Leukemia is a subtype of Acute Myeloid Leukemia (AML), characterized by the presence of more than 80% monoblasts in the bone marrow. It is a rare and aggressive form of leukemia, which primarily affects adults, but can also occur in children.

Etiology

The exact cause of Monoblastic Leukemia is unknown. However, it is believed to be caused by mutations in the DNA of a cell in the Bone Marrow. These mutations result in the cell becoming a leukemic cell, which then multiplies and accumulates in the bone marrow, eventually spilling over into the bloodstream.

Symptoms

Symptoms of Monoblastic Leukemia can vary, but often include fatigue, fever, bleeding or bruising easily, frequent infections, and weight loss. Some patients may also experience bone pain or tenderness, due to the accumulation of leukemic cells in the bone marrow.

Diagnosis

Diagnosis of Monoblastic Leukemia is typically made through a Bone Marrow Biopsy, which allows for the examination of the cells in the bone marrow. Additional tests, such as Cytogenetics and Flow Cytometry, may also be used to confirm the diagnosis and determine the specific subtype of AML.

Treatment

Treatment for Monoblastic Leukemia typically involves Chemotherapy, with the goal of achieving remission. In some cases, a Stem Cell Transplant may also be considered. The specific treatment plan will depend on a variety of factors, including the patient's overall health, age, and the specific characteristics of the leukemia.

Prognosis

The prognosis for Monoblastic Leukemia can vary widely, depending on a variety of factors. These include the patient's age, overall health, and the specific characteristics of the leukemia. In general, however, Monoblastic Leukemia is considered to be a more aggressive form of AML, with a poorer prognosis than some other subtypes.

See Also

• Acute Myeloid Leukemia
• Leukemia
• Bone Marrow Biopsy
• Chemotherapy