Mozavaptan
Mozavaptan is a vasopressin receptor antagonist used in the treatment of hyponatremia (low blood sodium levels) associated with syndrome of inappropriate antidiuretic hormone (SIADH). It was developed by Otsuka Pharmaceutical and is marketed under the brand name Samsca.
Mechanism of Action[edit | edit source]
Mozavaptan works by blocking the action of vasopressin, a hormone that regulates the body's water balance. By inhibiting the vasopressin V2 receptors in the kidneys, Mozavaptan increases the excretion of water, thereby increasing the concentration of sodium in the blood.
Clinical Use[edit | edit source]
Mozavaptan is used to treat hyponatremia in patients with SIADH, a condition in which the body produces too much antidiuretic hormone, leading to water retention and low sodium levels. It is also used in the treatment of autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder characterized by the growth of numerous cysts in the kidneys.
Side Effects[edit | edit source]
Common side effects of Mozavaptan include dry mouth, thirst, and increased urination. In rare cases, it can cause severe liver damage, leading to the need for a liver transplant.
Pharmacokinetics[edit | edit source]
Mozavaptan is taken orally and is metabolized in the liver by the cytochrome P450 enzyme system. It has a half-life of approximately 12 hours and is excreted primarily in the urine.
Regulatory Status[edit | edit source]
Mozavaptan was approved by the Food and Drug Administration (FDA) in the United States in 2009 for the treatment of hyponatremia. It is also approved for use in several other countries, including Japan and the European Union.
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
