Myelodysplastic–myeloproliferative diseases
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(Redirected from Myelodysplastic/myeloproliferative neoplasm)
| Myelodysplastic–myeloproliferative diseases
| |
|---|---|
| Specialty | Hematology |
| Symptoms | Fatigue, anemia, splenomegaly, fever |
| Complications | Acute myeloid leukemia, bone marrow failure
|
| Types | Chronic myelomonocytic leukemia, Atypical chronic myeloid leukemia, Juvenile myelomonocytic leukemia
|
| Diagnosis | Blood test, bone marrow biopsy
|
| Treatment | Chemotherapy, stem cell transplant
|
Myelodysplastic–myeloproliferative diseases (MDS/MPN) are a group of hematologic disorders characterized by features of both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). These diseases are marked by the abnormal growth and development of blood cells in the bone marrow, leading to a combination of cytopenias and cytoses.
Classification[edit]
Myelodysplastic–myeloproliferative diseases are classified into several subtypes, including:
- Chronic myelomonocytic leukemia (CMML)
- Atypical chronic myeloid leukemia (aCML)
- Juvenile myelomonocytic leukemia (JMML)
- Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U)
Symptoms[edit]
Common symptoms of MDS/MPN include:
Complications[edit]
Patients with MDS/MPN are at risk for developing:
Diagnosis[edit]
Diagnosis of MDS/MPN typically involves:
- Blood tests to evaluate blood cell counts and morphology
- Bone marrow biopsy to assess the cellularity and presence of dysplastic or proliferative features
Treatment[edit]
Treatment options for MDS/MPN may include:
