NCOA5
NCOA5 (Nuclear Receptor Coactivator 5) is a protein that in humans is encoded by the NCOA5 gene. This protein is part of the nuclear receptor coactivator family and plays a critical role in cellular processes such as cell cycle regulation and apoptosis.
Function[edit | edit source]
NCOA5 is a coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and cyclic AMP response element-binding protein (CREB) to the transcriptional complex. It plays a role in the regulation of the cell cycle and apoptosis.
Clinical significance[edit | edit source]
Alterations in the NCOA5 gene have been associated with an increased risk of type 2 diabetes and breast cancer. Studies have shown that NCOA5 is a potential tumor suppressor gene and its downregulation may contribute to the progression of breast cancer.
See also[edit | edit source]
References[edit | edit source]
Template:Genes on human chromosome 20
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Contributors: Prab R. Tumpati, MD
