NFE2L1

NFE2L1 (Nuclear Factor, Erythroid 2 Like 1), also known as NRF1 (Nuclear Respiratory Factor 1), is a protein that in humans is encoded by the NFE2L1 gene. It is a transcription factor that plays a crucial role in the regulation of genes involved in antioxidant response and cellular stress response.

Function

NFE2L1 is a member of the Cap 'n' Collar (CNC) family of transcription factors, which are characterized by a highly conserved basic region and leucine zipper (bZIP) domain. The protein binds to the antioxidant response element (ARE) and activates transcription of target genes. The antioxidant response element is found in the promoter region of genes involved in detoxification and protection against oxidative stress.

Clinical Significance

Alterations in the expression of NFE2L1 have been associated with several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. In cancer, NFE2L1 has been found to be overexpressed in certain types of tumors, suggesting a potential role in tumorigenesis. In neurodegenerative diseases, NFE2L1 has been implicated in the regulation of neuronal survival and the response to oxidative stress.

Research

Research into the role of NFE2L1 in disease is ongoing, with a particular focus on its potential as a therapeutic target. Studies have suggested that modulation of NFE2L1 activity could have beneficial effects in conditions characterized by oxidative stress, such as neurodegenerative diseases and cancer.

See Also

• NFE2L2
• NFE2L3
• Antioxidant response element
• Transcription factor