NFE2L3

NFE2L3 (Nuclear factor erythroid 2-related factor 3) is a protein that in humans is encoded by the NFE2L3 gene. It is a member of the Cap 'n' Collar type of basic region leucine zipper factor family (CNC-bZip) of transcription factors.

Function

NFE2L3 is a transcription factor that is involved in the regulation of cellular responses to oxidative stress. It is believed to play a role in the protection of cells from oxidative damage by regulating the expression of genes involved in antioxidant defense.

Structure

The NFE2L3 protein is composed of several domains, including a basic region that is involved in DNA binding, a leucine zipper region that is involved in protein-protein interactions, and a transactivation domain that is involved in the activation of transcription.

Clinical significance

Alterations in the expression of NFE2L3 have been associated with several types of cancer, including lung cancer, breast cancer, and colorectal cancer. It is thought that these alterations may contribute to the development and progression of these cancers by affecting the regulation of cellular responses to oxidative stress.

Research

Research is ongoing to further understand the role of NFE2L3 in cellular responses to oxidative stress and its potential as a target for the development of new treatments for cancer.

See also

• NFE2L2
• NFE2L1
• Oxidative stress
• Transcription factor