NLPHL

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma, accounting for approximately 5% of all cases. It is characterized by the presence of large, atypical B cells known as LP cells or popcorn cells. NLPHL is typically slow-growing and responds well to treatment, with a high overall survival rate.

Signs and Symptoms

Patients with NLPHL often present with painless, swollen lymph nodes, most commonly in the neck. Other symptoms may include fever, night sweats, and unexplained weight loss. However, many patients with NLPHL do not have any symptoms at the time of diagnosis.

Diagnosis

Diagnosis of NLPHL is typically made through a biopsy of an affected lymph node. The biopsy is examined under a microscope to look for the presence of LP cells. Additional tests, such as blood tests, imaging studies, and a bone marrow biopsy, may be performed to determine the extent of the disease.

Treatment

Treatment for NLPHL often involves chemotherapy, radiation therapy, or a combination of both. The choice of treatment depends on the stage of the disease, the patient's overall health, and the patient's personal preferences. Some patients with early-stage NLPHL may choose to undergo active surveillance instead of immediate treatment.

Prognosis

The prognosis for NLPHL is generally good, with a 10-year survival rate of over 90%. However, patients with NLPHL are at increased risk of developing secondary cancers, particularly non-Hodgkin lymphoma.

See Also

• Hodgkin lymphoma
• Non-Hodgkin lymphoma
• Lymph node
• Chemotherapy
• Radiation therapy

NLPHL Resources
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