NPR3

NPR3 (Natriuretic Peptide Receptor 3) is a protein that in humans is encoded by the NPR3 gene. It is a part of the natriuretic peptide receptor family and plays a significant role in the cardiovascular system and homeostasis.

Function

NPR3, also known as the clearance receptor, binds to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) to remove them from circulation. It does not have guanylyl cyclase activity and therefore does not generate cyclic GMP upon ligand binding. The receptor is heavily expressed in the kidney and is also found in the lung and adrenal gland.

Clinical Significance

Alterations in the NPR3 gene have been associated with hypertension and heart failure. Studies have shown that a decrease in NPR3 expression can lead to an increase in blood pressure. Furthermore, NPR3 has been implicated in the pathogenesis of cardiac hypertrophy and heart failure due to its role in regulating the natriuretic peptide system.

Research

Research into NPR3 has focused on its role in the cardiovascular system and its potential as a therapeutic target for heart failure and hypertension. Studies have also investigated the relationship between NPR3 and other natriuretic peptide receptors, such as NPR1 and NPR2.

See Also

• Natriuretic peptide receptor
• Atrial natriuretic peptide
• Brain natriuretic peptide
• Hypertension
• Heart failure

References

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