Nepadutant
Nepadutant is a drug that acts as a selective antagonist for the neurokinin 1 receptor. It was developed by Menarini and is used in the treatment of irritable bowel syndrome (IBS) and other gastrointestinal disorders.
Pharmacology[edit | edit source]
Nepadutant selectively blocks the neurokinin 1 (NK1) receptor. The neurokinin 1 receptor is a G protein-coupled receptor located in the central and peripheral nervous system. It is involved in various physiological processes, including pain perception and smooth muscle contraction in the gastrointestinal tract. By blocking this receptor, nepadutant can reduce the symptoms of IBS and other gastrointestinal disorders.
Clinical trials[edit | edit source]
Nepadutant has undergone Phase II clinical trials for the treatment of irritable bowel syndrome. The results of these trials have shown that nepadutant can significantly reduce the symptoms of IBS, including abdominal pain and discomfort, bloating, and altered bowel habits.
Side effects[edit | edit source]
The most common side effects of nepadutant include headache, dizziness, and gastrointestinal symptoms such as nausea and diarrhea. These side effects are generally mild and transient.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
