Nestorone

Nestorone (also known as Segesterone acetate) is a progestin medication which is used in contraceptive methods. It is a synthetic steroid and has been developed for use in female hormonal contraception, particularly in contraceptive implants and vaginal rings.

History

Nestorone was first described in the literature in 1979 and has been under investigation for use in contraception since the 1990s. It is not currently marketed for medical use, but is available for use in research.

Medical uses

Nestorone is used in contraceptive implants and vaginal rings. It is also being investigated for use in male hormonal contraception. In female contraception, it is often combined with an estrogen to prevent menstrual irregularities.

Pharmacology

As a progestin, Nestorone works primarily by preventing ovulation. It also thickens the cervical mucus, which helps to prevent sperm from reaching the egg. In addition, it thins the lining of the uterus, which makes it less likely that a fertilized egg can implant and grow.

Side effects

Common side effects of Nestorone include menstrual irregularities, breast tenderness, and nausea. Less common side effects include weight gain, mood changes, and acne.

Research

Nestorone is currently under investigation for use in male hormonal contraception. Early research suggests that it may be effective in this role, but further studies are needed.

See also

• Progestin
• Contraceptive implant
• Vaginal ring

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