Segesterone acetate
Segesterone acetate is a progestin of the 19-norprogesterone group which is used as a hormonal contraceptive. It is also known by its developmental code name Nestorone. Segesterone acetate is notable for its high potency and selectivity for the progesterone receptor.
Chemical Structure and Properties[edit | edit source]
Segesterone acetate is a synthetic steroid and a derivative of progesterone. Its chemical structure is characterized by the presence of an acetate group at the 17α position. This modification enhances its potency and duration of action compared to natural progesterone.
Mechanism of Action[edit | edit source]
As a progestin, segesterone acetate works primarily by binding to the progesterone receptor in target tissues. This binding inhibits ovulation by suppressing the secretion of gonadotropins from the pituitary gland. Additionally, it induces changes in the endometrium that make it less suitable for implantation and thickens the cervical mucus to prevent sperm penetration.
Clinical Uses[edit | edit source]
Segesterone acetate is used in combination with an estrogen in various forms of hormonal contraception, including vaginal rings and transdermal patches. It is particularly valued for its minimal androgenic and estrogenic side effects, making it suitable for a wide range of users.
Pharmacokinetics[edit | edit source]
Segesterone acetate is administered via non-oral routes such as vaginal rings or transdermal patches to avoid first-pass metabolism in the liver. This allows for more consistent and controlled release of the hormone into the bloodstream.
Side Effects[edit | edit source]
Common side effects of segesterone acetate include headache, nausea, breast tenderness, and irregular menstrual bleeding. Serious but rare side effects may include thromboembolism and hypertension.
Research and Development[edit | edit source]
Segesterone acetate has been the subject of extensive research for its potential use in male contraception and as a treatment for various gynecological disorders such as endometriosis and menorrhagia.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
