Neuromedin B receptor

Neuromedin B receptor (NMBR) is a protein that in humans is encoded by the NMBR gene. It is a member of the G protein-coupled receptor superfamily. This receptor is involved in the regulation of numerous physiological processes and has been implicated in various diseases, including cancer and obesity.

Structure

The Neuromedin B receptor is a 390-amino acid protein that is approximately 44 kDa in size. It is a seven-transmembrane receptor, which is a characteristic feature of G protein-coupled receptors. The receptor has an extracellular N-terminus and an intracellular C-terminus.

Function

The Neuromedin B receptor is a bombesin receptor subtype. It has high affinity for Neuromedin B, a 10-amino acid peptide that is highly expressed in the gastrointestinal tract and central nervous system. Neuromedin B acts as a potent mitogen and growth factor, and its receptor mediates its effects on cell proliferation, migration, and survival.

Clinical significance

Alterations in the expression or function of the Neuromedin B receptor have been associated with various diseases. Overexpression of the receptor has been observed in several types of cancer, including breast cancer, lung cancer, and prostate cancer. In addition, mutations in the NMBR gene have been linked to obesity.

See also

• Bombesin receptor
• Neuromedin B