Neuronal PAS domain protein 4

Neuronal PAS domain protein 4 (NPAS4) is a protein that in humans is encoded by the NPAS4 gene. It is a member of the Neuronal PAS domain protein family, which are transcription factors involved in the regulation of gene expression.

Function

NPAS4 is a transcription factor that is activated in response to neuronal activity. It is crucial for the formation of inhibitory synapses in the brain, which are necessary for the normal functioning of the nervous system. NPAS4 regulates the expression of a variety of genes, including those involved in neurotransmission, neuronal development, and neuronal survival.

Clinical significance

Alterations in the NPAS4 gene have been associated with a variety of neurological disorders, including autism, schizophrenia, and bipolar disorder. Further research is needed to fully understand the role of NPAS4 in these conditions.

See also

• Neuronal PAS domain protein 2
• Neuronal PAS domain protein 3

References

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