Neuropeptide Y receptor Y1

Neuropeptide Y receptor Y1 is a protein that in humans is encoded by the NPY1R gene. This receptor is a member of the neuropeptide Y receptors family, which are G protein-coupled receptors involved in various biological processes.

Function

The Neuropeptide Y receptor Y1 is a protein that interacts with neuropeptide Y, a molecule that acts as a neurotransmitter in the brain. This interaction plays a crucial role in the regulation of energy homeostasis, feeding behavior, and circadian rhythm. The receptor is also involved in the modulation of blood pressure and heart rate, and it has been implicated in the pathophysiology of obesity and anxiety.

Structure

The structure of the Neuropeptide Y receptor Y1 is characterized by seven transmembrane domains, a common feature of G protein-coupled receptors. The N-terminal end of the protein is located outside the cell, while the C-terminal end is inside the cell. The receptor's binding site for neuropeptide Y is located within the transmembrane domains.

Clinical significance

Alterations in the function of the Neuropeptide Y receptor Y1 have been associated with several diseases. For example, mutations in the NPY1R gene have been linked to obesity and type 2 diabetes. In addition, the receptor has been implicated in the development of anxiety disorders and depression.

See also

• Neuropeptide Y
• Neuropeptide Y receptors
• G protein-coupled receptor
• Obesity
• Type 2 diabetes
• Anxiety disorders
• Depression

References

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