Nitrazepate
Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and muscle relaxant properties.
Pharmacology[edit | edit source]
Nitrazepam is a long-acting benzodiazepine with a half-life of 16-38 hours. It affects the GABA receptors in the brain, enhancing the effects of the neurotransmitter GABA. This results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.
Medical uses[edit | edit source]
Nitrazepam is used for the short-term relief of severe, disabling anxiety and insomnia. It is also used for the management of epilepsy. However, it is not a first-line treatment for this condition.
Side effects[edit | edit source]
Common side effects of Nitrazepam include drowsiness, hypotonia, ataxia, and confusion. Less common side effects include changes in libido, tremors, and skin rash.
Dependence and withdrawal[edit | edit source]
Long-term use of Nitrazepam can lead to tolerance, dependence, and withdrawal syndrome upon discontinuation. The risk of dependence increases with higher doses and longer term use.
See also[edit | edit source]
Nitrazepate Resources | ||
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