Nucleoporin 107

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene. It is a component of the nuclear pore complex, a structure that regulates the movement of materials between the nucleus and the cytoplasm.

Function

Nup107 is part of the Nup107-160 subcomplex, which is a critical part of the nuclear pore complex. This subcomplex is involved in several key cellular processes, including mitosis, cell cycle progression, and nuclear envelope formation.

Structure

The NUP107 gene encodes a protein that is approximately 107 kDa in size. The protein is part of the larger Nup107-160 subcomplex, which also includes several other nucleoporins. This subcomplex forms a ring-like structure on the nuclear side of the nuclear pore complex.

Clinical significance

Mutations in the NUP107 gene have been associated with several diseases, including cancer and neurodegenerative diseases. In particular, alterations in Nup107 function have been implicated in the development of leukemia and glioblastoma, among other types of cancer.

Research

Research into Nup107 is ongoing, with studies focusing on its role in cell cycle regulation, its potential as a therapeutic target in cancer, and its involvement in neurodegenerative diseases.

See also

• Nuclear pore
• Nucleoporin
• Cell cycle
• Mitosis

References

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