Nucleoporin 88

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene. It is a component of the nuclear pore complex, a structure that regulates the transport of molecules between the nucleus and the cytoplasm.

Function

Nup88 is a non-FG nucleoporin that plays a crucial role in the bidirectional transport of RNA and protein across the nuclear pore complex. It is involved in the import of protein into the nucleus and the export of RNA and protein from the nucleus to the cytoplasm.

Structure

The NUP88 gene encodes a protein of 741 amino acids with a predicted molecular weight of approximately 88 kDa. The protein has a coiled-coil domain in its N-terminal half and is rich in leucine residues.

Clinical significance

Alterations in the expression of Nup88 have been associated with several types of cancer, including colorectal cancer, breast cancer, and lung cancer. Overexpression of Nup88 has been shown to disrupt the nuclear pore complex and contribute to the malignant progression of cancer.

See also

• Nuclear pore
• Nucleoporin
• NUP98