OSLAM syndrome

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OSLAM syndrome is a rare autosomal dominant hereditary disorder. Its name is an initialism of "osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow syndrome". OSLAM syndrome was recognised and described by Mulvilhill Template:Abbreviation as a syndrome that increases susceptibility to tumours and is characterised by an impaired regulation of bone and marrow development.[1][2]

Individuals with OSLAM syndrome have an elevated risk of bone cancer, limb abnormalities, and enlarged red blood cells.

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References[edit | edit source]

  1. Mulvihill J.J., Gralnick H.R., Whang-Peng J., Leventhal B.G. (1977.) Multiple childhood osteosarcomas in an American Indian family with erythoid macrocytosis and skeletal anomalies, Cancer, 40(6):3115–3122.
  2. Weber G.F. (2007.) Molecular Mechanisms of Cancer, Springer, pg. 558.

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Contributors: Prab R. Tumpati, MD