OSLAM syndrome
OSLAM syndrome is a rare autosomal dominant hereditary disorder. Its name is an initialism of "osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow syndrome". OSLAM syndrome was recognised and described by Mulvilhill Template:Abbreviation as a syndrome that increases susceptibility to tumours and is characterised by an impaired regulation of bone and marrow development.[1][2]
Individuals with OSLAM syndrome have an elevated risk of bone cancer, limb abnormalities, and enlarged red blood cells.
Symptoms[edit | edit source]
- Bone cancer
- Curved fifth fingers (clinodactyly) with brachymesophalangy (shortened phalanges of the toes and/or fingers (digits))
- Absence of one digital ray of the foot (a digit and corresponding metacarpal or metatarsal bone)
- Bilateral radioulnar synostosis
- Enlarged red blood cells
- Dental decay
- Short stature
Diagnosis[edit | edit source]
This section is empty. You can help by adding to it. (August 2017) |
Treatment[edit | edit source]
This section is empty. You can help by adding to it. (August 2017) |
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
Classification | |
---|---|
External resources |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD