Acipimox

Acipimox is a niacin derivative used as a lipid-lowering agent. It works by inhibiting the body's production of fatty acids and reducing levels of triglycerides and low-density lipoprotein (LDL) cholesterol, while increasing levels of high-density lipoprotein (HDL) cholesterol.

Pharmacology

Acipimox is a niacin derivative that has lipid-lowering properties. It inhibits the release of fatty acids from adipose tissue, leading to a decrease in triglycerides and low-density lipoprotein (LDL) cholesterol, and an increase in high-density lipoprotein (HDL) cholesterol.

Clinical Use

Acipimox is used in the treatment of hyperlipidemia and dyslipidemia. It is particularly effective in reducing levels of triglycerides and low-density lipoprotein (LDL) cholesterol, and increasing levels of high-density lipoprotein (HDL) cholesterol.

Side Effects

Common side effects of Acipimox include flushing, itching, nausea, abdominal pain, and headache. In rare cases, it can cause hypotension, dizziness, and rash.

Contraindications

Acipimox is contraindicated in patients with liver disease, peptic ulcer disease, and gout. It should be used with caution in patients with diabetes due to the potential for hyperglycemia.

Interactions

Acipimox may interact with other lipid-lowering agents, antihypertensives, and anticoagulants. It may also interact with alcohol, which can increase the risk of flushing and itching.

See Also

• Niacin
• Hyperlipidemia
• Dyslipidemia

Acipimox Resources
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