PBX2

PBX2 is a protein that in humans is encoded by the PBX2 gene. This protein is part of the PBX homeobox family, a group of transcription factors that play key roles in embryonic development and cell differentiation.

Function

The PBX2 protein is a member of the PBX homeobox family of transcription factors. These proteins are characterized by a highly conserved homeodomain, which is a 60-amino acid sequence that binds DNA. PBX proteins are known to form heterodimers with other proteins, enhancing the DNA-binding affinity of their partners and providing additional specificity to their binding.

PBX2, like other members of the PBX family, is believed to play a crucial role in embryonic development. It is involved in the regulation of cell proliferation, cell differentiation, and apoptosis, processes that are essential for the proper formation and function of tissues and organs in the body.

Clinical Significance

Alterations in the PBX2 gene or its protein product have been implicated in various diseases. For instance, overexpression of PBX2 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis. Further research is needed to fully understand the role of PBX2 in disease development and progression.

See Also

• PBX homeobox family
• Homeobox
• Transcription factor
• Gene
• Protein