PBX3

PBX3 (Pre-B-cell leukemia homeobox 3) is a protein that in humans is encoded by the PBX3 gene. It is a member of the PBX homeobox family of transcriptional factors.

Function

PBX3 is a homeobox gene, a family of genes that play key roles in regulating development and cell differentiation. It is involved in the regulation of morphogenesis and organogenesis during embryonic development. PBX3 is also implicated in the development of certain types of cancer, including leukemia and breast cancer.

Structure

The PBX3 protein is a transcription factor, meaning it binds to specific sequences of DNA and controls the transcription of genetic information from DNA to mRNA. It contains a homeobox domain, which is a sequence of about 60 amino acids that is responsible for binding to DNA.

Clinical significance

Alterations in the expression of PBX3 have been associated with various types of cancer. Overexpression of PBX3 has been observed in acute myeloid leukemia (AML) and is associated with poor prognosis. In breast cancer, PBX3 promotes tumor growth and metastasis.

Research

Research into PBX3 is ongoing, with studies focusing on its role in cancer development and potential as a therapeutic target.

See also

• PBX1
• PBX2
• Homeobox

References

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