PDGFA
PDGFA (Platelet-Derived Growth Factor Subunit A) is a protein that in humans is encoded by the PDGFA gene. This protein is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.
Function[edit | edit source]
The PDGFA protein is a potent mitogen for cells of mesenchymal origin. It plays a crucial role in wound healing and during embryonic development. It is involved in organogenesis, embryogenesis, and wound healing, primarily through its role in cell proliferation, migration, and angiogenesis.
Clinical Significance[edit | edit source]
Abnormalities in PDGFA or its receptor can result in various health disorders. Overexpression of PDGFA has been linked to asthma, rheumatoid arthritis, and certain types of cancer. It is also implicated in diseases characterized by excessive fibrosis such as pulmonary fibrosis and liver cirrhosis.
Interactions[edit | edit source]
PDGFA interacts with the PDGF receptor, a class III receptor tyrosine kinase. This interaction leads to receptor dimerization and autophosphorylation, which triggers a cascade of downstream signaling events.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
