PDGFB
PDGFB (Platelet-derived growth factor subunit B) is a protein that in humans is encoded by the PDGFB gene. It is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteine residues.
Function[edit | edit source]
The PDGFB gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB). These two forms function as growth factors that stimulate the proliferation of cells of mesenchymal origin, including fibroblasts, smooth muscle cells, and glial cells.
Clinical significance[edit | edit source]
Mutations in this gene are associated with idiopathic basal ganglia calcification and dermatofibrosarcoma protuberans. Overexpression of PDGFB has been observed in certain tumors such as astrocytomas and glioblastoma multiforme.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
