Glioblastoma multiforme

Glioblastoma multiforme (GBM) is the most common and deadliest of malignant primary brain tumors in adults. It is categorized as a grade IV astrocytoma, a tumor that arises from the supportive tissue of the brain. GBM develops from the proliferation of astrocytes and other types of brain cells.

Symptoms

The symptoms of GBM are initially non-specific. They may include headache, nausea, vomiting, and drowsiness. As the tumor grows, it may cause other symptoms such as seizure, memory loss, personality changes, and neurological deficits.

Diagnosis

Diagnosis of GBM involves a neurological examination, imaging tests, and a biopsy. The imaging tests may include MRI and CT scan. The biopsy involves removing a small piece of the tumor to examine under a microscope.

Treatment

Treatment for GBM may involve surgery, radiation therapy, and chemotherapy. The goal of treatment is to remove as much of the tumor as possible, to relieve symptoms, and to improve quality of life.

Prognosis

The prognosis for GBM is generally poor. The average survival time is 12 to 15 months, with fewer than 3% to 5% of people surviving longer than five years.

Research

Research into new treatments for GBM is ongoing. These include immunotherapy, gene therapy, and targeted therapy.

See also

• Brain tumor
• Astrocytoma
• Neuro-oncology

References

Glioblastoma multiforme Resources
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