Ganglioglioma

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Ganglioglioma
Micrograph of a ganglioglioma, a type of brain tumor
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Seizures, headache, nausea, vomiting, neurological deficits
Complications Increased intracranial pressure, hydrocephalus
Onset Typically in children and young adults
Duration Variable
Types WHO grade I, WHO grade II
Causes Unknown
Risks Genetic predisposition
Diagnosis MRI, CT scan, biopsy
Differential diagnosis Astrocytoma, oligodendroglioma, dysembryoplastic neuroepithelial tumor
Prevention N/A
Treatment Surgical resection, radiotherapy, chemotherapy
Medication N/A
Prognosis Generally favorable with complete resection
Frequency Rare
Deaths N/A


Ganglioglioma is a rare type of brain tumor that arises from a combination of neurons and glial cells. It is classified as a glioma, a type of tumor that originates from the glial cells in the brain or spine. Gangliogliomas are generally considered to be low-grade tumors, meaning they grow slowly and are less likely to spread to other parts of the body.

Epidemiology[edit | edit source]

Gangliogliomas account for approximately 1% of all primary brain tumors. They are most commonly diagnosed in children and young adults, with a peak incidence in the first three decades of life. Both males and females are equally affected by this type of tumor.

Pathophysiology[edit | edit source]

Gangliogliomas are composed of both neuronal and glial components. The neuronal component consists of ganglion cells, while the glial component is typically made up of astrocytes. These tumors often arise in the temporal lobe of the brain, which is associated with the control of seizures.

Clinical Presentation[edit | edit source]

The most common symptom of ganglioglioma is seizures, which occur in approximately 80% of patients. Other symptoms may include headache, nausea, vomiting, and neurological deficits depending on the tumor's location.

Diagnosis[edit | edit source]

The diagnosis of ganglioglioma typically involves a combination of neuroimaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) scans. These imaging studies help to identify the location and extent of the tumor. A definitive diagnosis is made through a biopsy and subsequent histopathological examination, which reveals the characteristic mixed neuronal and glial cell composition.

Treatment[edit | edit source]

The primary treatment for ganglioglioma is surgical resection. The goal of surgery is to remove as much of the tumor as possible while preserving neurological function. In cases where the tumor cannot be completely resected, additional treatments such as radiation therapy or chemotherapy may be considered. However, these tumors are generally less responsive to these modalities compared to other types of brain tumors.

Prognosis[edit | edit source]

The prognosis for patients with ganglioglioma is generally favorable, especially for those who undergo complete surgical resection. The 5-year survival rate is high, and many patients experience long-term seizure control following surgery. However, the prognosis can vary depending on factors such as the tumor's location, size, and the extent of resection.

See Also[edit | edit source]

References[edit | edit source]



External Links[edit | edit source]

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Contributors: Prab R. Tumpati, MD