Malignant peripheral nerve sheath tumor
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
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| Malignant peripheral nerve sheath tumor | |
|---|---|
| |
| Synonyms | MPNST, neurofibrosarcoma, malignant schwannoma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Pain, neurological deficits, palpable mass |
| Complications | Metastasis, local recurrence |
| Onset | Typically in adulthood |
| Duration | Variable |
| Types | N/A |
| Causes | Often associated with neurofibromatosis type I |
| Risks | Neurofibromatosis, prior radiation therapy |
| Diagnosis | Biopsy, imaging studies |
| Differential diagnosis | Schwannoma, neurofibroma, fibrosarcoma |
| Prevention | N/A |
| Treatment | Surgery, radiation therapy, chemotherapy |
| Medication | N/A |
| Prognosis | Generally poor, depends on stage and resectability |
| Frequency | Rare, <0.1% of all cancers |
| Deaths | N/A |
Malignant peripheral nerve sheath tumor (MPNST) is a rare form of cancer that originates from the peripheral nerve sheath, the protective layer that surrounds nerves. These tumors are often aggressive and can spread to other parts of the body.
Symptoms[edit | edit source]
The symptoms of MPNST can vary depending on the location of the tumor. Common symptoms include a growing lump or mass, pain or discomfort, and neurological problems such as numbness or weakness.
Causes[edit | edit source]
The exact cause of MPNST is unknown, but it is often associated with certain genetic conditions such as Neurofibromatosis type 1 (NF1) and Schwannomatosis.
Diagnosis[edit | edit source]
Diagnosis of MPNST typically involves a combination of physical examination, imaging tests such as MRI or CT scan, and biopsy.
Treatment[edit | edit source]
Treatment for MPNST often involves surgery to remove the tumor, followed by radiation therapy or chemotherapy to kill any remaining cancer cells.
Prognosis[edit | edit source]
The prognosis for MPNST varies depending on factors such as the size and location of the tumor, the patient's overall health, and the success of treatment.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
