Insulin-like growth factor 2

From WikiMD's WELLNESSPEDIA

Insulin-like growth factor 2 (IGF-2) is a protein that in humans is encoded by the IGF2 gene. IGF-2 is a member of the insulin family of hormones, which play a key role in growth and development.

Function[edit]

IGF-2 is an important regulator of cell growth and cell division. It is particularly critical during fetal development, but continues to have effects throughout life. IGF-2 is produced by the liver and other tissues, and its production is controlled by growth hormone.

Structure[edit]

The IGF-2 protein is a single-chain polypeptide consisting of 67 amino acids. It shares structural similarities with insulin, including the presence of three disulfide bonds.

Clinical significance[edit]

Alterations in the function of IGF-2 are associated with a variety of diseases. Overexpression of IGF-2 is seen in many cancers, including breast cancer, colon cancer, and lung cancer. Conversely, reduced levels of IGF-2 are associated with growth retardation and developmental delay.

See also[edit]

References[edit]


External links[edit]

Stub icon

This protein-related article is a stub. You can help WikiMD by expanding the page.

Stub icon

This medical article is a stub. You can help WikiMD by expanding the page.


Sponsored Health Resource

W8MD weight loss success

W8MD Weight Loss, Sleep & MedSpa

Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.

GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.

Book a W8MD appointment · View GLP-1 specials

Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=Insulin-like_growth_factor_2&oldid=6530633"