Insulin-like growth factor 2
Insulin-like growth factor 2 (IGF-2) is a protein that in humans is encoded by the IGF2 gene. IGF-2 is a member of the insulin family of hormones, which play a key role in growth and development.
Function[edit | edit source]
IGF-2 is an important regulator of cell growth and cell division. It is particularly critical during fetal development, but continues to have effects throughout life. IGF-2 is produced by the liver and other tissues, and its production is controlled by growth hormone.
Structure[edit | edit source]
The IGF-2 protein is a single-chain polypeptide consisting of 67 amino acids. It shares structural similarities with insulin, including the presence of three disulfide bonds.
Clinical significance[edit | edit source]
Alterations in the function of IGF-2 are associated with a variety of diseases. Overexpression of IGF-2 is seen in many cancers, including breast cancer, colon cancer, and lung cancer. Conversely, reduced levels of IGF-2 are associated with growth retardation and developmental delay.
See also[edit | edit source]
- Insulin-like growth factor 1
- Insulin-like growth factor 2 receptor
- Insulin-like growth factor-binding protein
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
