Insulin-like growth factor 2

Insulin-like growth factor 2 (IGF-2) is a protein that in humans is encoded by the IGF2 gene. IGF-2 is a member of the insulin family of hormones, which play a key role in growth and development.

Function

IGF-2 is an important regulator of cell growth and cell division. It is particularly critical during fetal development, but continues to have effects throughout life. IGF-2 is produced by the liver and other tissues, and its production is controlled by growth hormone.

Structure

The IGF-2 protein is a single-chain polypeptide consisting of 67 amino acids. It shares structural similarities with insulin, including the presence of three disulfide bonds.

Clinical significance

Alterations in the function of IGF-2 are associated with a variety of diseases. Overexpression of IGF-2 is seen in many cancers, including breast cancer, colon cancer, and lung cancer. Conversely, reduced levels of IGF-2 are associated with growth retardation and developmental delay.

See also

• Insulin-like growth factor 1
• Insulin-like growth factor 2 receptor
• Insulin-like growth factor-binding protein

External links

• GeneCards - IGF2