Insulin-like growth factor 2 receptor

Insulin-like growth factor 2 receptor (IGF2R) is a protein that in humans is encoded by the IGF2R gene. It is a multifunctional protein receptor that binds Insulin-like growth factor 2 (IGF2) as well as other ligands.

Function

The IGF2R is a molecule that is part of the cell membrane and is involved in the transport of IGF2 from the cell surface to the inside of the cell. This process is known as endocytosis. The receptor also has a role in the degradation of IGF2, a protein that promotes cell growth and cell division.

In addition to IGF2, the IGF2R can bind other ligands, including mannose-6-phosphate (M6P), which is involved in the transport of certain enzymes to lysosomes.

Clinical significance

Mutations in the IGF2R gene have been associated with various diseases, including cancer. Overexpression of IGF2R has been observed in some types of cancer, suggesting that it may play a role in tumor growth and progression.

In addition, studies have suggested that IGF2R may be involved in the development of insulin resistance, a condition that is a major risk factor for type 2 diabetes.

See also

• Insulin-like growth factor 2
• Insulin-like growth factor 1 receptor
• Insulin receptor