Pefloxacin

From WikiMD's Wellness Encyclopedia

(Redirected from PFLX)

Pefloxacin is a quinolone drug used to treat bacterial infections. It is a synthetic antibacterial agent and belongs to the group of fluoroquinolones. Pefloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Mechanism of Action[edit | edit source]

Pefloxacin works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Uses[edit | edit source]

Pefloxacin is used to treat severe and life-threatening bacterial infections such as pneumonia, urinary tract infections, gonorrhea, and skin infections. It is also used in the treatment of tuberculosis when first-line drugs cannot be used.

Side Effects[edit | edit source]

Like all medicines, Pefloxacin can cause side effects, although not everybody gets them. The most common side effects include nausea, diarrhea, vomiting, and rash. In rare cases, it can cause serious side effects like tendon rupture, photosensitivity, and QT prolongation.

Precautions[edit | edit source]

Pefloxacin should be used with caution in patients with a history of tendon disorders related to fluoroquinolone treatment. It should not be used in patients with a history of epilepsy or seizures. It should also be avoided in patients with known QT interval prolongation or patients who are taking other drugs that prolong the QT interval.

Interactions[edit | edit source]

Pefloxacin may interact with other medications, including antacids, iron salts, multivitamins, and didanosine. These interactions can affect the absorption of Pefloxacin and reduce its effectiveness.

References[edit | edit source]

Pefloxacin Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD