PLAG1

PLAG1 (Pleomorphic Adenoma Gene 1) is a gene that encodes a protein playing a crucial role in various biological processes, including cell growth and cell division. This gene is located on the chromosome 8 (8q12.1) in humans.

Function

The PLAG1 gene encodes a zinc finger protein that functions as a transcription factor. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to nearby DNA. The PLAG1 protein specifically binds to DNA sequences containing the motif 5'-GGGCGG-3'.

Clinical Significance

Alterations in the PLAG1 gene are associated with a variety of tumors, most notably pleomorphic adenoma of the salivary glands. Pleomorphic adenoma is a benign, slow-growing tumor that often presents as a painless, firm, mobile mass within the affected gland.

Chromosome translocation involving the PLAG1 gene is a common genetic alteration in these tumors. This translocation results in the fusion of PLAG1 with another gene, leading to the overexpression of the PLAG1 protein. This overexpression is believed to contribute to the development and growth of the tumor.

Research

Research into the PLAG1 gene and its associated protein continues to be a significant area of interest in the field of oncology. Understanding the mechanisms by which PLAG1 contributes to tumor development may lead to new therapeutic strategies for treating pleomorphic adenoma and other tumors associated with this gene.

See Also

• Pleomorphic adenoma
• Transcription factor
• Zinc finger protein
• Chromosome 8