PRM2

PRM2 is a gene that encodes for the protein Protamine 2 in humans. This protein is a member of the protamine family and plays a crucial role in sperm development.

Function

The PRM2 gene provides instructions for making a protein called protamine 2. This protein is found in the nucleus of sperm cells, where it binds to and condenses the DNA into a compact, stable form. This condensation is essential for the sperm cell's ability to fertilize an egg.

Structure

The PRM2 gene is located on the short (p) arm of chromosome 16 at position 13.2. More precisely, the PRM2 gene is located from base pair 15,560,801 to base pair 15,561,293 on chromosome 16.

Clinical significance

Mutations in the PRM2 gene have been associated with male infertility. Some studies suggest that these mutations may affect the structure and function of sperm, preventing them from effectively fertilizing an egg.

See also

• Protamine
• Sperm
• DNA
• Chromosome 16
• Infertility

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