Pappenheimer

Pappenheimer bodies are abnormal granules of iron found inside red blood cells. They are named after American pathologist James Homer Wright, who first described them in 1905. Pappenheimer bodies are seen in certain types of anemia, especially sideroblastic anemia and sickle cell anemia. They can also be seen in people with thalassemia and in those who have had a splenectomy.

Appearance

Pappenheimer bodies appear as small, round, blue-purple granules within red blood cells when stained with Wright's stain. They are usually found in the periphery of the cell. They can be seen under a light microscope.

Causes

Pappenheimer bodies are caused by the abnormal accumulation of iron within red blood cells. This can occur in conditions where the body is unable to properly use or store iron, such as sideroblastic anemia and thalassemia. They can also occur in conditions where the red blood cells are being destroyed too quickly, such as sickle cell anemia.

Diagnosis

The presence of Pappenheimer bodies can be confirmed by a blood smear and Prussian blue staining, which highlights the iron granules. They can also be detected by an automated blood cell counter, although this method is less accurate.

Treatment

Treatment for Pappenheimer bodies involves treating the underlying condition causing the abnormal iron accumulation. This may involve iron chelation therapy for conditions like sideroblastic anemia and thalassemia, or blood transfusions for conditions like sickle cell anemia.

See also

• Anemia
• Sideroblastic anemia
• Sickle cell anemia
• Thalassemia
• Splenectomy

Pappenheimer Resources
Latest articles Most recent articles Ongoing trials	Wikipedia