Pauci-immune

From WikiMD's Wellnesspedia

Pauci-immune is a term used in medicine to describe a condition where there is a minimal amount of immune deposits found in the walls of small blood vessels. This condition is often associated with vasculitis, a group of rare diseases that involve inflammation of the blood vessels.

Overview[edit | edit source]

Pauci-immune conditions are often characterized by the absence of antibodies or immune complexes in the walls of the blood vessels. This is in contrast to other forms of vasculitis, where these immune deposits are often present.

The most common diseases associated with pauci-immune conditions are granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). These diseases are also known as ANCA-associated vasculitis as they are often associated with anti-neutrophil cytoplasmic antibodies (ANCA).

Symptoms[edit | edit source]

The symptoms of pauci-immune conditions can vary widely depending on the specific disease and the organs affected. However, common symptoms can include fever, fatigue, weight loss, and muscle pain. In severe cases, these conditions can lead to kidney failure or lung disease.

Diagnosis[edit | edit source]

Diagnosis of pauci-immune conditions often involves a combination of blood tests, imaging studies, and biopsies. Blood tests can detect the presence of ANCA, while imaging studies such as CT scans or MRI can help identify any damage to the organs. Biopsies can confirm the diagnosis by showing the absence of immune deposits in the blood vessels.

Treatment[edit | edit source]

Treatment for pauci-immune conditions typically involves immunosuppressive therapy to reduce inflammation and prevent further damage to the organs. This can include medications such as corticosteroids and cyclophosphamide. In severe cases, plasma exchange may be used.

See also[edit | edit source]


Pauci-immune Resources

Find a healthcare provider anywhere in the world quickly and easily!

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD