Perfosfamide
4-Hydroperoxycyclophosphamide[edit | edit source]
4-Hydroperoxycyclophosphamide is a chemical compound that serves as a prodrug of cyclophosphamide, a widely used chemotherapy agent. It is an important compound in the field of oncology due to its role in the activation of cyclophosphamide, which is used to treat various types of cancer.
Chemical Properties[edit | edit source]
4-Hydroperoxycyclophosphamide is a cytotoxic compound that belongs to the class of oxazaphosphorines. It is characterized by the presence of a hydroperoxy group, which is crucial for its function as a prodrug. The chemical structure of 4-Hydroperoxycyclophosphamide allows it to be converted into the active form of cyclophosphamide in the body.
Mechanism of Action[edit | edit source]
The primary mechanism of action of 4-Hydroperoxycyclophosphamide involves its conversion into phosphoramide mustard, the active metabolite of cyclophosphamide. This conversion occurs through a series of biochemical reactions in the liver. Once activated, phosphoramide mustard forms DNA cross-links in cancer cells, leading to cell death. This process is particularly effective in rapidly dividing cells, such as those found in tumors.
Clinical Applications[edit | edit source]
4-Hydroperoxycyclophosphamide is used in clinical research and experimental therapies to study the effects of cyclophosphamide in a controlled manner. It is not typically administered directly to patients but is used in laboratory settings to understand the pharmacokinetics and pharmacodynamics of cyclophosphamide.
Safety and Handling[edit | edit source]
As a potent cytotoxic agent, 4-Hydroperoxycyclophosphamide must be handled with care in laboratory settings. Proper safety protocols should be followed to prevent exposure, including the use of personal protective equipment and fume hoods.
Related Pages[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD