Perimysium

Perimysium is a sheath of connective tissue that groups muscle fibers into bundles (anywhere between 10 to 100 or more) or fascicles. Each bundle or fascicle is wrapped in a layer of connective tissue called the perimysium. This name comes from the Greek words 'peri', which means 'around' or 'surrounding', and 'mysium', which refers to muscle tissue.

Structure

The perimysium is made up of dense irregular connective tissue, which includes type I collagen and elastin. It also contains blood vessels and nerves that provide the muscle fibers with the necessary nutrients and signals for contraction. The perimysium is responsible for carrying the major blood vessels and nerves to the muscle fibers.

Function

The main function of the perimysium is to bind together muscle fibers into fascicles, providing an avenue for nerves and blood vessels to reach the individual muscle fibers. This organization is crucial for the functioning of muscles as it allows for the efficient transmission of forces generated by muscle fibers to the tendons and, ultimately, to the skeleton.

Clinical significance

Damage to the perimysium can lead to a variety of medical conditions. For example, in Duchenne muscular dystrophy, the perimysium becomes thickened and fibrotic, leading to muscle weakness and wasting. In polymyositis, inflammation of the perimysium can lead to muscle pain and weakness.

See also

• Endomysium
• Epimysium
• Muscle tissue
• Connective tissue

References

Perimysium Resources
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