Pfizer–BioNTech COVID-19 vaccine

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Pfizer-BioNTech COVID-19 vaccine (2020) E

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Boxes containing the COVID-19 vaccines

Inside view of the Pfizer factory

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Pfizer–BioNTech COVID-19 vaccine

The Pfizer–BioNTech COVID-19 vaccine, also known as BNT162b2, is a COVID-19 vaccine developed by BioNTech, a German biotechnology company, and Pfizer, an American pharmaceutical corporation. It is one of the first vaccines authorized for emergency use to combat the COVID-19 pandemic.

Development and Approval

The vaccine was developed using messenger RNA (mRNA) technology, which instructs cells to produce a protein that triggers an immune response. The development process was expedited through a series of clinical trials that demonstrated its safety and efficacy. The vaccine received Emergency Use Authorization (EUA) from the United States Food and Drug Administration (FDA) in December 2020, followed by similar authorizations from regulatory agencies in other countries.

Mechanism of Action

The Pfizer–BioNTech COVID-19 vaccine uses mRNA to encode the spike protein of the SARS-CoV-2 virus. Once administered, the mRNA is taken up by cells, which then produce the spike protein. This protein is recognized by the immune system, prompting the production of antibodies and activating T-cells, which provide immunity against the virus.

Efficacy and Safety

Clinical trials have shown that the vaccine has an efficacy rate of approximately 95% in preventing symptomatic COVID-19 infection. Common side effects include pain at the injection site, fatigue, headache, and fever. Rare but serious side effects, such as myocarditis and anaphylaxis, have also been reported.

Distribution and Administration

The vaccine is administered in two doses, given three weeks apart. It requires storage at ultra-low temperatures, which has posed logistical challenges for distribution. The vaccine has been distributed globally, with priority given to healthcare workers, elderly individuals, and those with underlying health conditions.

Variants and Booster Shots

The emergence of SARS-CoV-2 variants has raised concerns about the vaccine's efficacy. Studies have shown that the vaccine remains effective against several variants, although booster shots are being developed and administered to enhance immunity.

Public Reception and Impact

The Pfizer–BioNTech COVID-19 vaccine has played a crucial role in the global effort to control the COVID-19 pandemic. It has been widely praised for its high efficacy and rapid development. However, vaccine hesitancy and unequal distribution remain significant challenges.

See Also

• Moderna COVID-19 vaccine
• AstraZeneca COVID-19 vaccine
• Johnson & Johnson COVID-19 vaccine
• COVID-19 vaccination
• COVID-19 pandemic