Phosphatidylserine synthase 1

Phosphatidylserine synthase 1 (PSS1) is an enzyme that in humans is encoded by the PSS1 gene. This enzyme is involved in the biosynthesis of phosphatidylserine, a key component of the cell membrane.

Function

Phosphatidylserine synthase 1 is one of two enzymes involved in the production of phosphatidylserine. The other enzyme is phosphatidylserine synthase 2 (PSS2). These enzymes catalyze the reaction that converts phosphatidylcholine and phosphatidylethanolamine to phosphatidylserine and diacylglycerol.

Phosphatidylserine is a crucial component of the cell membrane, playing a key role in cell signaling, apoptosis (programmed cell death), and the coagulation cascade.

Clinical significance

Mutations in the PSS1 gene have been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. Further research is needed to fully understand the role of PSS1 in these conditions.

See also

• Phosphatidylserine
• Phosphatidylserine synthase 2
• Cell membrane
• Biosynthesis

References

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