Piceatannol
Overview[edit | edit source]
Piceatannol is a naturally occurring stilbenoid, a type of phenolic compound found in various plants. It is a hydroxylated analog of resveratrol, with an additional hydroxyl group. Piceatannol is known for its potential antioxidant, anti-inflammatory, and anticancer properties.
Chemical Structure[edit | edit source]
Piceatannol is chemically classified as a stilbene, characterized by a 1,2-diphenylethylene backbone. Its IUPAC name is 3,3',4,5'-tetrahydroxystilbene. The presence of four hydroxyl groups contributes to its high reactivity and biological activity.
Sources[edit | edit source]
Piceatannol is found in a variety of plant sources, including grapes, berries, and passion fruit. It is also present in red wine, where it contributes to the beverage's health benefits. The compound is biosynthesized in plants as a defense mechanism against pathogens and UV radiation.
Biological Activity[edit | edit source]
Piceatannol exhibits several biological activities:
Antioxidant Properties[edit | edit source]
Piceatannol acts as a potent antioxidant, scavenging free radicals and protecting cells from oxidative stress. This activity is attributed to its ability to donate hydrogen atoms from its hydroxyl groups.
Anti-inflammatory Effects[edit | edit source]
The compound has been shown to inhibit the production of pro-inflammatory cytokines and enzymes such as cyclooxygenase and lipoxygenase, thereby reducing inflammation.
Anticancer Potential[edit | edit source]
Piceatannol has demonstrated anticancer properties by inducing apoptosis in various cancer cell lines. It interferes with cell cycle progression and inhibits angiogenesis, the formation of new blood vessels that tumors need to grow.
Metabolism[edit | edit source]
In the human body, piceatannol is metabolized by phase II enzymes, including glucuronidation and sulfation. These metabolic pathways enhance its solubility and facilitate its excretion.
Research and Applications[edit | edit source]
Research on piceatannol is ongoing, with studies exploring its potential therapeutic applications in cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. Its role as a dietary supplement is also being investigated.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
