Pituitary adenylate cyclase-activating peptide
Pituitary adenylate cyclase-activating peptide (PACAP) is a protein that in humans is encoded by the ADCYAP1 gene. It is a member of the secretin family of hormones and plays a critical role in the functioning of the central nervous system and the endocrine system.
Function[edit | edit source]
PACAP is a potent activator of adenylate cyclase, an enzyme involved in the production of cyclic AMP, a key messenger molecule in cells. It is involved in the regulation of numerous physiological processes, including neurotransmission, cell proliferation, and hormone secretion.
Structure[edit | edit source]
PACAP is a 38-amino acid peptide that shares significant structural similarities with other members of the secretin family, including vasoactive intestinal peptide (VIP) and growth hormone-releasing hormone (GHRH).
Clinical significance[edit | edit source]
Alterations in PACAP function have been implicated in a variety of diseases, including migraine, post-traumatic stress disorder (PTSD), and schizophrenia. It is also being investigated as a potential therapeutic target for these and other conditions.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
