Pleuropericardial folds

Pleuropericardial Folds

The pleuropericardial folds are embryological structures that play a crucial role in the development of the thoracic cavity and the pericardium. These folds are essential in the partitioning of the coelomic cavity into the pleural and pericardial cavities.

Development

The pleuropericardial folds appear during the early stages of embryonic development. They originate from the lateral walls of the primitive thoracic cavity and grow medially towards the midline. As they extend, they envelop the phrenic nerve and the common cardinal veins, which later become the superior vena cava.

The fusion of the pleuropericardial folds with the mesoderm of the esophagus and the septum transversum results in the formation of the fibrous pericardium, which encases the heart.

Function

The primary function of the pleuropericardial folds is to separate the developing lungs from the heart. This separation is crucial for the proper formation of the respiratory system and the circulatory system. The folds contribute to the formation of the pleural cavities, which house the lungs, and the pericardial cavity, which contains the heart.

Clinical Significance

Abnormal development of the pleuropericardial folds can lead to congenital anomalies such as pericardial cysts or defects in the pericardium. These conditions can have significant implications for the function of the heart and lungs and may require medical intervention.

Related Pages

• Thoracic cavity
• Pericardium
• Pleural cavity
• Phrenic nerve
• Superior vena cava
• Mesoderm
• Septum transversum
• Respiratory system
• Circulatory system
• Pericardial cyst