Prajmaline

Prajmaline is a class Ia antiarrhythmic agent. It is often used in the treatment of arrhythmias and is a derivative of Ajmaline, with similar antiarrhythmic properties.

Pharmacology

Prajmaline is a Class Ia antiarrhythmic agent, a group of pharmaceuticals that work by blocking the rapid inward sodium current. This results in a loss of phase 0 depolarization with a resultant decrease in the action potential duration. In general, the class Ia agents have intermediate kinetics of onset and offset of block, meaning that their effect size is in between the class Ib and Ic agents.

Medical Uses

Prajmaline is used in the treatment of various types of cardiac arrhythmias, including both ventricular and supraventricular (atrial) arrhythmias.

Side Effects

The side effects of Prajmaline are similar to those of other class Ia antiarrhythmic agents. The most common side effects include dizziness, blurred vision, and nausea. More serious side effects may include cardiac arrhythmias, including torsades de pointes, and other serious cardiac adverse events.

See Also

• Ajmaline
• Antiarrhythmic agent
• Cardiac arrhythmia

References

Prajmaline Resources
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