Cefonicid
(Redirected from Praticef)
Cefonicid is a second-generation cephalosporin antibiotic used in the treatment of various bacterial infections. It is a beta-lactam antibiotic that works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Cefonicid is particularly effective against Gram-positive bacteria and some Gram-negative bacteria, making it a useful agent in the treatment of infections such as pneumonia, skin infections, and urinary tract infections (UTIs).
Mechanism of Action[edit | edit source]
Cefonicid inhibits the synthesis of the bacterial cell wall by binding to penicillin-binding proteins (PBPs). This binding interferes with the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. The result is the weakening of the bacterial cell wall and ultimately cell lysis and death.
Pharmacokinetics[edit | edit source]
After administration, cefonicid is well distributed throughout the body, including in the pleural fluid, synovial fluid, and bone. It has a longer half-life compared to many other cephalosporins, which allows for once-daily dosing. Cefonicid is primarily excreted unchanged in the urine.
Clinical Uses[edit | edit source]
Cefonicid is used to treat a variety of bacterial infections, including:
It is also used as a prophylactic agent in certain surgical procedures to prevent postoperative infections.
Side Effects[edit | edit source]
Common side effects of cefonicid include:
As with all antibiotics, there is a risk of developing Clostridium difficile-associated diarrhea (CDAD) due to the alteration of the normal flora of the colon.
Contraindications[edit | edit source]
Cefonicid is contraindicated in patients with a known allergy to cephalosporins. Caution is advised in patients with a history of penicillin allergy, as cross-reactivity may occur.
Drug Interactions[edit | edit source]
Cefonicid may interact with other medications, such as:
- Probenecid, which can increase the concentration of cefonicid by decreasing its renal excretion.
- Anticoagulants (e.g., warfarin), as cefonicid may enhance the anticoagulant effect.
Conclusion[edit | edit source]
Cefonicid is a valuable antibiotic in the treatment of various bacterial infections due to its broad spectrum of activity and once-daily dosing. However, like all antibiotics, it should be used judiciously to prevent the development of resistance.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD